Biochemistry
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Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species
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Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production
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Enzymatic access to the rare ΔUA (1→4) Glc 3, 6, N-sulfated heparin disaccharide, implications for heparin quality control
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Curcuma longa Essential Oil Topically Mitigates Inflammatory Markers in Acetone-Induced Atopic Dermatitis in Wistar Albino Rats
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Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
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The conserved biochemical activity and function of an early metazoan phosphatidylinositol 5 phosphate 4-kinase regulates growth and development
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Medium-sized protein language models perform well at transfer learning on realistic datasets
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Acetylation of RORβ by histone acetyltransferase p300 and deacetylation by SIRT1 modulates receptor stability, turnover and transcriptional activity
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Computational enzyme design by catalytic motif scaffolding
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Allosteric modulation of the Lon protease by effector binding and local charges
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