Biochemistry
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Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain
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Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development
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Crystal structures of bacterial Small Multidrug Resistance transporter EmrE in complex with structurally diverse substrates
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Determinants of trafficking, conduction, and disease within a K + channel revealed through multiparametric deep mutational scanning
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Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors
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Zinc pyrithione is a potent inhibitor of PL Pro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication
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Inhibitory proteins block substrate access by occupying the active site cleft of Bacillus subtilis intramembrane protease SpoIVFB
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Emergent properties of a mitotic Kif18b-MCAK-EB network
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Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening
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Flipped Over U: Structural Basis for dsRNA Cleavage by the SARS-CoV-2 Endoribonuclease
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