Biochemistry
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Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease
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Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-Assembly
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Selectivity of Protein Interactions along the Aggregation Pathway of α-Synuclein
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Skd3 (human CLPB ) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations
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Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry
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Bariatric surgery reveals a gut-restricted TGR5 agonist that exhibits anti-diabetic effects
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Tsetse salivary glycoproteins are modified with paucimannosidic N -glycans, are recognised by C-type lectins and bind to trypanosomes
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Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones
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A complex containing lysine-acetylated actin inhibits the formin INF2
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Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification
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