Synthetic Biology
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Mapping targetable sites on the human surfaceome for the design of novel binders
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Chai-1: Decoding the molecular interactions of life
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A molecular proximity sensor based on an engineered, dual-component guide RNA
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De novo -designed minibinders expand the synthetic biology sensing repertoire
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A synthetic method to assay polycystin channel biophysics
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Light-driven synchronization of optogenetic clocks
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Design of highly functional genome editors by modeling the universe of CRISPR-Cas sequences
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Targeted protein degradation systems to enhance Wnt signaling
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Highly multiplexed design of an allosteric transcription factor to sense novel ligands
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Specific Modulation of CRISPR Transcriptional Activators through RNA-Sensing Guide RNAs in Mammalian Cells and Zebrafish Embryos
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