GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome

  1. Boris Simovski
  2. Daniel Vodak
  3. Sveinung Gundersen
  4. Diana Domanska
  5. Abdulrahman Azab
  6. Lars Holden
  7. Marit Holden
  8. Ivar Grytten
  9. Knut Rand
  10. Finn Drabløs
  11. Morten Johansen
  12. Antonio Mora
  13. Christin Lund-Andersen
  14. Bastian Fromm
  15. Ragnhild Eskeland
  16. Odd Stokke Gabrielsen
  17. Sigve Nakken
  18. Mads Bengtsen
  19. Alexander Johan Nederbragt
  20. Hildur Sif Thorarensen
  21. Johannes Andreas Akse
  22. Ingrid Glad
  23. Eivind Hovig
  24. Geir Kjetil Sandve
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Abstract

Genome-wide, cell-type-specific profiles are being systematically generated for numerous genomic and epigenomic features. There is, however, no universally applicable analytical methodology for such data. We present GSuite HyperBrowser, the first comprehensive solution for integrative analysis of dataset collections across the genome and epigenome. The GSuite HyperBrowser is an open-source system for streamlined acquisition and customizable statistical analysis of large collections of genome-wide datasets. The system is based on new computational and statistical methodologies that permit comparative and confirmatory analyses across multiple disparate data sources. Expert guidance and reproducibility are facilitated via a Galaxy-based web-interface. The software is available at<ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://hyperbrowser.uio.no/gsuite">https://hyperbrowser.uio.no/gsuite</ext-link>

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