FUSTr: a tool to find gene Families Under Selection in Transcriptomes

FUSTr is a tool for finding genes in transcriptomic datasets under strong positive selection that automatically detects isoform designation patterns in transcriptome assemblies to maximize phylogenetic independence in downstream analysis. When applied to previously studied spider toxin families as well as simulated data, FUSTr successfully grouped coding sequences into proper gene families as well as correctly identified those under strong positive selection. FUSTr provides a tool capable of utilizing multi-processor high-performance computational facilities and is scalable for large transcriptomic biodiversity datasets.