Restoration of leukomonocyte counts is associated with viral clearance in COVID-19 hospitalized patients

  1. Xiaoping Chen
  2. Jiaxin Ling
  3. Pingzheng Mo
  4. Yongxi Zhang
  5. Qunqun Jiang
  6. Zhiyong Ma
  7. Qian Cao
  8. Wenjia Hu
  9. Shi Zou
  10. Liangjun Chen
  11. Lei Yao
  12. Mingqi Luo
  13. Tielong Chen
  14. Liping Deng
  15. Ke Liang
  16. Shihui Song
  17. Rongrong Yang
  18. Ruiying Zheng
  19. Shicheng Gao
  20. Xien Gui
  21. Hengning Ke
  22. Wei Hou
  23. Ã…ke Lundkvist
  24. Yong Xiong
1 evaluations Published on
Read the full article Related papers
This article on Sciety

Abstract

Background

Viral clearance is one important indicator for the recovery of SARS-CoV-2 infected patients. Previous studies have pointed out that suboptimal T and B cell responses can delay viral clearance in MERS-CoV and SARS-CoV infected patients. The role of leukomonocytes in viral clearance of COVID-19 patients is not yet well defined.

Methods

From January 26 to February 28, 2020, an observational study was launched at the Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China. We enrolled 25 laboratory-confirmed COVID-19 patients, whose throat-swab specimens were tested positive for SARS-CoV-2 infection by qRT-PCR. To investigate the factors that contribute to the viral clearance, we comprehensively analyzed clinical records, counts of lymphocyte subsets including CD3+, CD4+, CD8+ T cells, B cells and NK cells in the patients who successfully cleared SARS-CoV-2, and compared to those that failed to, after a standardized treatment of 8-14 days.

Findings

In 25 enrolled COVID-19 patients, lymphopenia was a common feature. After the treatment, 14 out of the 25 enrolled patients were tested negative for SARS-CoV-2. The patients that cleared the infection had restored the numbers of CD3+, CD4+, CD8+ T cells and B cells as compared to the still viral RNA positive patients, while the recovered patients had a higher count of leukomonocytes.

Conclusions

By comparison of leukomonocytes counts in COVID-19 patients at different stages of the disease, we found that CD3+, CD4+, CD8+ T cells and B cells appear to play important roles in viral clearance. The restoration of leukomonocytes counts from peripheral blood can be used as prognosis for the recovery of an COVID-19 infection. We propose that restoration of leukomonocytes counts can be added to the COVID-19 diagnostic guidance as a criterion for releasing and discharging patients.

Related articles

Related articles are currently not available for this article.