A human monoclonal antibody blocking SARS-CoV-2 infection

  1. Chunyan Wang
  2. Wentao Li
  3. Dubravka Drabek
  4. Nisreen M.A. Okba
  5. Rien van Haperen
  6. Albert D.M.E. Osterhaus
  7. Frank J.M. van Kuppeveld
  8. Bart L. Haagmans
  9. Frank Grosveld
  10. Berend-Jan Bosch
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Abstract

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV). This cross-neutralizing antibody targets a communal epitope on these viruses and offers potential for prevention and treatment of COVID-19.

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