Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses

  1. K. Reddisiva Prasanth
  2. Minato Hirano
  3. W. Samuel Fagg
  4. Eileen T. McAnarney
  5. Chao Shan
  6. Xuping Xie
  7. Adam Hage
  8. Colette A. Pietzsch
  9. Alexander Bukreyev
  10. Ricardo Rajsbaum
  11. Pei-Yong Shi
  12. Mark T. Bedford
  13. Shelton S. Bradrick
  14. Vineet Menachery
  15. Mariano A. Garcia-Blanco
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Abstract

Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-ß (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.

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