Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein

  1. Chek Meng Poh
  2. Guillaume Carissimo
  3. Bei Wang
  4. Siti Naqiah Amrun
  5. Cheryl Yi-Pin Lee
  6. Rhonda Sin-Ling Chee
  7. Nicholas Kim-Wah Yeo
  8. Wen-Hsin Lee
  9. Yee-Sin Leo
  10. Mark I-Cheng Chen
  11. Seow-Yen Tan
  12. Louis Yi Ann Chai
  13. Shirin Kalimuddin
  14. Siew-Yee Thien
  15. Barnaby Edward Young
  16. David C. Lye
  17. Cheng-I Wang
  18. Laurent Renia
  19. Lisa F.P. Ng
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Abstract

The ongoing SARS-CoV-2 pandemic demands rapid identification of immunogenic targets for the design of efficient vaccines and serological detection tools. In this report, using pools of overlapping linear peptides and functional assays, we present two immunodominant regions on the spike glycoprotein that were highly recognized by neutralizing antibodies in the sera of COVID-19 convalescent patients. One is highly specific to SARS-CoV-2, and the other is a potential pan-coronavirus target.

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