The QT Interval in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine/Azithromycin

  1. Ehud Chorin
  2. Matthew Dai
  3. Eric Shulman
  4. Lalit Wadhwani
  5. Roi-Bar-Cohen
  6. Chirag Barbhaiya
  7. Anthony Aizer
  8. Douglas Holmes
  9. Scott Bernstein
  10. Michael Spinelli
  11. David S. Park
  12. Larry A. Chinitz
  13. Lior Jankelson
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Abstract

We report the change in the QT interval in 84 adult patients with SARS-CoV-2 infection treated with Hydroxychloroquine/Azithromycin combination. QTc prolonged maximally from baseline between days 3 and 4. in 30% of patients QTc increased by greater than 40ms. In 11% of patients QTc increased to >500 ms, representing high risk group for arrhythmia. The development of acute renal failure but not baseline QTc was a strong predictor of extreme QTc prolongation.

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