COVID-19: A model correlating BCG vaccination to protection from mortality implicates trained immunity

  1. Cameron M. Green
  2. Stephanie Fanucchi
  3. Jorge Dominguez-Andres
  4. Ezio T. Fok
  5. Simone J.C.F.M. Moorlag
  6. Yutaka Negishi
  7. Leo A. B. Joosten
  8. Mihai G. Netea
  9. Musa M. Mhlanga
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Abstract

  • We use a data quality model to demonstrate that BCG vaccination is correlated with protection from death from COVID19

  • From a mechanistic perspective, BCG is well described to elicit its protective non-specific effects through the process of trained immunity.

  • Therapeutically enhancing trained immunity may therefore be an important mechanism in protection from the lethal effects of COVID19

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