Rapid SARS-CoV-2 whole genome sequencing for informed public health decision making in the Netherlands

  1. Bas B. Oude Munnink
  2. David F. Nieuwenhuijse
  3. Mart Stein
  4. Áine O’Toole
  5. Manon Haverkate
  6. Madelief Mollers
  7. Sandra K. Kamga
  8. Claudia Schapendonk
  9. Mark Pronk
  10. Pascal Lexmond
  11. Anne van der Linden
  12. Theo Bestebroer
  13. Irina Chestakova
  14. Ronald J. Overmars
  15. Stefan van Nieuwkoop
  16. Richard Molenkamp
  17. Annemiek van der Eijk
  18. Corine GeurtsvanKessel
  19. Harry Vennema
  20. Adam Meijer
  21. Andrew Rambaut
  22. Jaap van Dissel
  23. Reina S. Sikkema
  24. Aura Timen
  25. Marion Koopmans
  26. on behalf of the Dutch-Covid-19 response team
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Abstract

SARS-CoV-2 is a novel coronavirus that has rapidly spread across the globe. In the Netherlands, the first case of SARS-CoV-2 has been notified on the 27th of February. Here, we describe the first three weeks of the SARS-CoV-2 outbreak in the Netherlands, which started with several different introductory events from Italy, Austria, Germany and France followed by local amplification in, and later also, outside the South of the Netherlands. The timely generation of whole genome sequences combined with epidemiological investigations facilitated early decision making in an attempt to control local transmission of SARS-CoV-2 in the Netherlands.

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