Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable

  1. Frances MK Williams
  2. Maxim B Freidin
  3. Massimo Mangino
  4. Simon Couvreur
  5. Alessia Visconti
  6. Ruth CE Bowyer
  7. Caroline I Le Roy
  8. Mario Falchi
  9. Carole Sudre
  10. Richard Davies
  11. Christopher Hammond
  12. Cristina Menni
  13. Claire J Steves
  14. Tim D Spector
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Abstract

Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n=2633) completing the C-19 Covid symptom tracker app allowed classical twin studies of covid-19 symptoms including predicted covid-19, a symptom-based algorithm predicting true infection derived in app users tested for SARS-CoV-2. We found heritability for fever = 41 (95% confidence intervals 12-70)%; anosmia 47 (27-67)%; delirium 49 (24-75)%; and predicted covid-19 gave heritability = 50 (29-70)%.

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