Towards the next phase: evaluation of serological assays for diagnostics and exposure assessment

  1. Corine H. GeurtsvanKessel
  2. Nisreen M.A. Okba
  3. Zsofia Igloi
  4. Carmen W.E. Embregts
  5. Brigitta M. Laksono
  6. Lonneke Leijten
  7. Janette Rahamat-Langendoen
  8. Johannes P.C. van den Akker
  9. Jeroen J.A. van Kampen
  10. Annemiek A. van der Eijk
  11. Rob S. van Binnendijk
  12. Bart Haagmans
  13. Marion Koopmans
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Abstract

The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a comprehensive comparison of serological COVID-19 assays. We show that the assay detecting total immunoglobulins against the receptor binding domain of SARS CoV-2, had optimal characteristics for antibody detection in different stages of disease.

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