Genetic structure of SARS-CoV-2 in Western Germany reflects clonal superspreading and multiple independent introduction events

  1. Andreas Walker
  2. Torsten Houwaart
  3. Tobias Wienemann
  4. Malte Kohns Vasconcelos
  5. Daniel Strelow
  6. Tina Senff
  7. Lisanna Hülse
  8. Ortwin Adams
  9. Marcel Andree
  10. Sandra Hauka
  11. Torsten Feldt
  12. Björn-Erik Jensen
  13. Verena Keitel
  14. Detlef Kindgen-Milles
  15. Jörg Timm
  16. Klaus Pfeffer
  17. Alexander T Dilthey
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Abstract

We whole-genome sequenced 55 SARS-CoV-2 isolates from Western Germany and investigated the genetic structure of SARS-CoV-2 outbreaks in the Heinsberg district and Düsseldorf. While the genetic structure of the Heinsberg outbreak indicates a clonal origin, reflective of superspreading dynamics during the carnival season, distinct viral strains are circulating in Düsseldorf, reflecting the city’s international links. Limited detection of Heinsberg strains in the Düsseldorf area despite geographical proximity may reflect efficient containment and contact tracing efforts.

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