Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs

  1. Xabier Michelena
  2. Helena Borrell
  3. Mireia L贸pez-Corbeto
  4. Mar铆a L贸pez-Lasanta
  5. Estefan铆a Moreno
  6. Mar铆a Pascual-Pastor
  7. Alba Erra
  8. Mayte Serrat
  9. Esther Espartal
  10. Susana Ant贸n
  11. Gustavo Adolfo A帽ez
  12. Raquel Caparr贸s-Ruiz
  13. Andrea Pluma
  14. Ernesto Trallero-Aragu谩s
  15. Mireia Barcel贸-Bru
  16. Miriam Almirall
  17. Juan Jos茅 De Agust铆n
  18. Jordi Llad贸s Segura
  19. Antonio Juli脿
  20. Sara Marsal
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Abstract

OBJECTIVES

To investigate the incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases receiving targeted biologic and synthetic disease modifying anti-rheumatic drugs (tDMARDs) and to explore the possible effect of these treatments in the clinical expression of COVID-19.

METHODS

A cross-sectional study comprising of a telephone survey and electronic health records review was performed including all adult and paediatric patients with rheumatic diseases treated with tDMARDs in a large rheumatology tertiary centre in Barcelona, Spain. Demographics, disease activity, COVID-19 related symptoms and contact history data were obtained from the start of the 2020 pandemic. Cumulative incidence of confirmed cases (SARS-CoV-2 positive PCR test) was compared to the population estimates for the same city districts from a governmental COVID-19 health database. Suspected cases were defined following WHO criteria and compared to those without compatible symptoms.

RESULTS

959 patients with rheumatic diseases treated with tDMARDs were included. We identified 11 confirmed SARS-CoV-2 positive cases in the adult cohort and no confirmed positive cases in the paediatric cohort. All patients had a successful recovery and only one patient required admission in the intensive care unit. When using the same classification criteria (only COVID-19 positive cases with pneumonia), COVID-19 incidence rates of the rheumatic patient cohort were very similar to that of the general population [(0.48% (95% CI 0.09 to 8.65%)] and [0.58% (95% CI 5.62 to 5.99%)], respectively. We found significant differences in tDMARDs proportions between the suspected and non-suspected cases (p=0.002).

CONCLUSION

Adult and paediatric patients with rheumatic diseases on tDMARDs do not seem to present a higher risk of COVID-19 or a more severe disease outcome when compared to general population. Our exploratory analysis suggests that the proportion of COVID-19 suspected cases differs between tDMARDs.

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