Suboptimal biological sampling as a probable cause of false-negative COVID-19 diagnostic test results

  1. Natalie N. Kinloch
  2. Gordon Ritchie
  3. Chanson J. Brumme
  4. Winnie Dong
  5. Weiyan Dong
  6. Tanya Lawson
  7. R. Brad Jones
  8. Julio S.G. Montaner
  9. Victor Leung
  10. Marc G. Romney
  11. Aleksandra Stefanovic
  12. Nancy Matic
  13. Christopher F. Lowe
  14. Zabrina L. Brumme
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Abstract

Improper nasopharyngeal swab collection could contribute to false-negative COVID-19 results. In support of this, specimens from confirmed or suspected COVID-19 cases that tested negative or indeterminate ( i.e. suspected false-negatives) contained less human DNA (a stable molecular marker of sampling quality) compared to a representative pool of specimens submitted for testing.

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