Clinical characteristics and early outcomes in patients with COVID-19 treated with tocilizumab at a United States academic center

  1. Casey A. Rimland
  2. Camille E. Morgan
  3. Griffin J. Bell
  4. Min K. Kim
  5. Tanner Hedrick
  6. Ashley Marx
  7. Brian Bramson
  8. Heidi Swygard
  9. Sonia Napravnik
  10. John L. Schmitz
  11. Shannon S. Carson
  12. William A. Fischer
  13. Joseph J. Eron
  14. Cynthia L. Gay
  15. Jonathan B. Parr
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Abstract

We describe early outcomes in 11 COVID-19 patients treated with the IL-6 receptor inhibitor tocilizumab. While C-reactive protein decreased, neither clinical improvement nor reduced temperature or oxygen requirements was observed in most patients. Our findings contrast with prior reports and raise questions about tocilizumab use in severe COVID-19.

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