Multi-Antigenic Virus-like Particle of SARS CoV-2 produced inSaccharomyces cerevisiaeas a vaccine candidate

  1. Kajal Arora
  2. Ruchir Rastogi
  3. Nupur Mehrotra Arora
  4. Deepak Parashar
  5. Jeny Paliwal
  6. Aelia Naqvi
  7. Apoorva Srivastava
  8. Sudhir Kumar Singh
  9. Sriganesh Kalyanaraman
  10. Swaroop Potdar
  11. Devanand Kumar
  12. Vidya Bhushan Arya
  13. Sarthi Bansal
  14. Satabdi Rautray
  15. Indrajeet Singh
  16. Pankaj Surendra Fengade
  17. Bibekanand Kumar
  18. Prabuddha Kumar Kundu
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Abstract

Spike, Envelope and Membrane proteins from the SARS CoV-2 virus surface coat are important vaccine targets. We hereby report recombinant co-expression of the three proteins (Spike, Envelope and Membrane) in a engineeredSaccharomyces cerevisiaeplatform (D-Crypt™) and their self-assembly as Virus-like particle (VLP). This design as a multi-antigenic VLP for SARS CoV-2 has the potential to be a scalable vaccine candidate. The VLP is confirmed by transmission electron microscopy (TEM) images of the SARS CoV-2, along with supportive HPLC, Dynamic Light Scattering (DLS) and allied analytical data. The images clearly outline the presence of a “Corona” like morphology, and uniform size distribution.

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