Changes in RT-PCR-positive SARS-CoV-2 rates in adults and children according to the epidemic stages

  1. Corinne Levy
  2. Romain Basmaci
  3. Philippe Bensaid
  4. CĂ©cile Bost Bru
  5. Edeline Coinde
  6. Emmanuelle Dessioux
  7. CĂ©cile Fournial
  8. Jean Gashignard
  9. Hervé Haas
  10. VĂ©ronique Hentgen
  11. Frédéric Huet
  12. Muriel Lalande
  13. Alain Martinot
  14. Charlotte Pons
  15. Anne Sophie Romain
  16. Nicoleta Ursulescu
  17. François Vie Le Sage
  18. Josette Raymond
  19. Stéphane Béchet
  20. Julie Toubiana
  21. Robert Cohen
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Abstract

Aim

To describe the trends of RT-PCR positive SARS-CoV-2 rates in children and adults according to the time of COVID-19 epidemic.

Methods

In this prospective multicenter study involving 45 pediatric units, we collected the results of nasopharyngeal swabs in France from March 2, 2020 to April 26, 2020.

Results

During the study period, 52,588 RT-PCR tests for SARS-CoV-2 were performed, 6,490 in children and 46,098 in adults. The risk ratio of RT-PCR positive SARS-CoV-2 tests for adults compared to children was 3.5 (95% CI [3.2;3.9]) for the whole study period. These rates varied according to the time of the epidemic and were higher at the peak. The lower rates of positive test in children persisted during the surveillance period but varied according to the time in the epidemic.

Conclusion

The rate of positive RT-PCR positive SARS-CoV-2 tests for children was always less than that for adults but vary according to the epidemic stage.

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