Anti-SARS-CoV-2 IgG antibodies are associated with reduced viral load

  1. Andrew Bryan
  2. Susan L. Fink
  3. Meghan A. Gattuso
  4. Gregory Pepper
  5. Anu Chaudhary
  6. Mark H. Wener
  7. Chihiro Morishima
  8. Keith R. Jerome
  9. Patrick C. Mathias
  10. Alexander L. Greninger
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Abstract

Anti-SARS-CoV-2 antibodies have been described, but correlation with virologic outcomes is limited. Here, we find anti-SARS-CoV-2 IgG to be associated with reduced viral load. High viral loads were rare in individuals who had seroconverted. Higher viral load on admission was associated with increased 30-day mortality (OR 4.20 [95% CI: 1.62-10.86]).

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