Preliminary analysis of scRNA sequencing of children’s lung tissues excludes the expression of SARS-CoV-2 entry related genes as the key reason for the milder syndromes of COVID-19 in children

  1. Yue Tao
  2. Ruwen Yang
  3. Chen Wen
  4. Jue Fan
  5. Jing Ma
  6. Qiao He
  7. Zhiguang Zhao
  8. Xinyu Song
  9. Hao Chen
  10. Guocheng Shi
  11. Minzhi Yin
  12. Nan Fang
  13. Hao Zhang
  14. Huiwen Chen
  15. Xi Mo
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Abstract

To explore whether the expression levels of viral-entry associated genes might contribute to the milder symptoms in children, we analyzed the expression of these genes in both children and adults’ lung tissues by single cell RNA sequencing (scRNA-seq) and immunohistochemistry (IHC). Both scRNA-seq and IHC analyses showed comparable levels of the key genes for SARS-CoV-2 entry in children and adults, includingACE2, TMPRSS2andFURIN, suggesting that instead of lower virus intrusion rate, other factors are more likely to be the key reasons for the milder symptoms of SARS-CoV-2 infected children.

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