Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections

  1. Henry M Staines
  2. Daniela E Kirwan
  3. David J Clark
  4. Emily R Adams
  5. Yolanda Augustin
  6. Rachel L Byrne
  7. Michael Cocozza
  8. Ana I Cubas-Atienzar
  9. Luis E. Cuevas
  10. Martina Cusinato
  11. Benedict M O Davies
  12. Mark Davis
  13. Paul Davis
  14. Annelyse Duvoix
  15. Nicholas M Eckersley
  16. Daniel Forton
  17. Alice J Fraser
  18. Gala Garrod
  19. Linda Hadcocks
  20. Qinxue Hu
  21. Michael Johnson
  22. Grant A Kay
  23. Kesja Klekotko
  24. Zawditu Lewis
  25. Derek C Macallan
  26. Josephine Mensah-Kane
  27. Stefanie Menzies
  28. Irene Monahan
  29. Catherine M Moore
  30. Gerhard Nebe-von-Caron
  31. Sophie I Owen
  32. Chris Sainter
  33. Amadou A Sall
  34. James Schouten
  35. Chris Williams
  36. John Wilkins
  37. Kevin Woolston
  38. Joseph R A Fitchett
  39. Sanjeev Krishna
  40. Tim Planche
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Abstract

We report dynamics of seroconversion to SARS-CoV-2 infections detected by IgG ELISA in 177 individuals diagnosed by RT-PCR. Longitudinal analysis identifies 2-8.5% of individuals who do not seroconvert even weeks after infection. They are younger than seroconverters who have increased co-morbidity and higher inflammatory markers such as C-Reactive Protein. Higher antibody responses are associated with non-white ethnicity. Antibody responses do not decline during follow up almost to 2 months. Serological assays increase understanding of disease severity. Their application in regular surveillance will clarify the duration and protective nature of humoral responses to SARS-CoV-2.

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