Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

  1. Yang Li
  2. Dan-yun Lai
  3. Hai-nan Zhang
  4. He-wei Jiang
  5. Xiao-long Tian
  6. Ming-liang Ma
  7. Huan Qi
  8. Qing-feng Meng
  9. Shu-juan Guo
  10. Yan-ling Wu
  11. Wei Wang
  12. Xiao Yang
  13. Da-wei Shi
  14. Jun-biao Dai
  15. Tian-lei Ying
  16. Jie Zhou
  17. Sheng-ce Tao
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Abstract

SARS-CoV-2 outbreak is a world-wide pandemic. The Spike protein plays central role in cell entry of the virus, and triggers significant immuno-response. Our understanding of the immune-response against S protein is still very limited. Herein, we constructed a peptide microarray and analyzed 55 convalescent sera, three areas with rich linear epitopes were identified. Potent neutralizing antibodies enriched from sera by 3 peptides, which do not belong to RBD were revealed.

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