Hydroxychloroquine inhibits trained immunity – implications for COVID-19

  1. Nils Rother
  2. Cansu Yanginlar
  3. Rik G.H. Lindeboom
  4. Siroon Bekkering
  5. Mandy M.T. van Leent
  6. Baranca Buijsers
  7. Inge Jonkman
  8. Mark de Graaf
  9. Marijke Baltissen
  10. Lieke A. Lamers
  11. Niels P. Riksen
  12. Zahi A. Fayad
  13. Willem J.M. Mulder
  14. Luuk B. Hilbrands
  15. Leo A.B. Joosten
  16. Mihai G. Netea
  17. Michiel Vermeulen
  18. Johan van der Vlag
  19. Raphaël Duivenvoorden
1 evaluations Published on
Read the full article Related papers
This article on Sciety

Abstract

SARS-CoV-2 infection can cause severe disease for which currently no specific therapy is available. The use of hydroxychloroquine to prevent or treat SARS-CoV-2 infection is controversial and its mode of action poorly understood. We demonstrate that hydroxychloroquine inhibits trained immunity at the functional and epigenetic level and is accompanied by profound changes in the cellular lipidome as well as reduced expression of interferon-stimulated genes. Trained immunity comprises a functional adaptation induced by epigenetic reprogramming which facilitates the anti-viral innate immune response. Our findings therefore suggest that hydroxychloroquine may not have a beneficial effect on the anti-viral immune response to SARS-CoV-2.

Related articles

Related articles are currently not available for this article.