SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease

  1. Pengfei Wang
  2. Lihong Liu
  3. Manoj S. Nair
  4. Michael T. Yin
  5. Yang Luo
  6. Qian Wang
  7. Ting Yuan
  8. Kanako Mori
  9. Axel Guzman Solis
  10. Masahiro Yamashita
  11. Lawrence J. Purpura
  12. Justin C. Laracy
  13. Jian Yu
  14. Joseph Sodroski
  15. Yaoxing Huang
  16. David D. Ho
1 evaluations Published on
Read the full article Related papers
This article on Sciety

Abstract

We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ~5-fold and ~7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.

Related articles

Related articles are currently not available for this article.