Monocyte CD169 expression as a biomarker in the early diagnosis of COVID-19

  1. Anne-Sophie Bedin
  2. Alain Makinson
  3. Marie-Christine Picot
  4. Frank Mennechet
  5. Fabrice Malergue
  6. Amandine Pisoni
  7. Esperance Nyiramigisha
  8. Lise Montagnier
  9. Karine Bollore
  10. Ségolène Debiesse
  11. David Morquin
  12. Penelope Bourgoin
  13. Nicolas Veyrenche
  14. Constance Renault
  15. Vincent Foulongne
  16. Caroline Bret
  17. Arnaud Bourdin
  18. Vincent Le Moing
  19. Philippe Van de Perre
  20. Edouard Tuaillon
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Abstract

We assessed the expression of the cell adhesion molecule Sialoadhesin (CD169), a type I interferon-inducible receptor, on monocytes (mCD169) in 53 adult patients admitted to the hospital during the COVID-19 outbreak for a suspicion of SARS-CoV-2 infection. mCD169 was strongly overexpressed in 30 out of 32 (93.7%) confirmed COVID-19 cases, compared to three out of 21 (14.3%) patients for whom the diagnosis of COVID-19 was finally ruled out. mCD169 was associated with the plasma interferon alpha level and thrombocytopenia. mCD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.

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