Limited specificity of serologic tests for SARS-CoV-2 antibody detection, Benin, Western Africa

  1. Anges Yadouleton
  2. Anna-Lena Sander
  3. Andres Moreira-Soto
  4. Carine Tchibozo
  5. Gildas Hounkanrin
  6. Yvette Badou
  7. Carlo Fischer
  8. Nina Krause
  9. Petas Akogbeto
  10. Edmilson F. de Oliveira Filho
  11. Anges Dossou
  12. Sebastian Brünink
  13. Melchior A. Joël AÏssi
  14. Mamoudou Harouna Djingarey
  15. Benjamin Hounkpatin
  16. Michael Nagel
  17. Jan Felix Drexler
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Abstract

Testing 68 RT-PCR-confirmed COVID-19 cases and controls from Benin, Western Africa with commercially available SARS-CoV-2 antibody ELISAs revealed up to 25% false-positive results, likely due to unspecific antibody responses elicited by acute malaria. Serologic tests must be carefully evaluated to robustly assess SARS-CoV-2 spread and immunity in tropical regions.

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