Covid-19 and dysregulated cerebral perfusion: observations with multimodal MRI

  1. Marie-Cécile Henry-Feugeas
  2. Augustin Gaudemer
  3. Xavier Lescure
  4. Antoine Dossier
  5. Romain Sonneville
  6. Carsten Ehmer
  7. Christophe Choquet
  8. Theresa Israel
  9. Agathe Raynaud Simon
  10. Raphael Borie
  11. Pierre Amarenco
  12. Antoine Khalil
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Abstract

The pathogenesis of encephalopathy-associated Covid-19 is still unclear. Multimodal brain MRI in 25 Covid-19 patients with neurological symptoms revealed angiographic and brain perfusion changes suggesting an under-recognized dysregulated brain perfusion not identified by morphological neuroimaging alone. Endothelial dysfunction, a key pathomechanism of dysregulated brain perfusion, may contribute to central-nervous-system disturbances in Covid-19.

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