Kinetics of SARS-CoV-2 Antibody Avidity Maturation and Association with Disease Severity

  1. Yiqi Ruben Luo
  2. Indrani Chakraborty
  3. Cassandra Yun
  4. Alan H.B. Wu
  5. Kara L. Lynch
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Abstract

The kinetics of IgG avidity maturation during SARS-CoV-2 infection was studied. The IgG avidity assay used a novel label-free immunoassay technology. It was found that there was a strong correlation between IgG avidity and days since symptom onset, and peak readings were significantly higher in severe than mild disease cases.

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