Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer

  1. Jiuxin Qu
  2. Zhao Cai
  3. Yumei Liu
  4. XiangKe Duan
  5. Shuhong Han
  6. Yuao Zhu
  7. Zhaofang Jiang
  8. Yingdan Zhang
  9. Chao Zhuo
  10. Yang Liu
  11. Yingxia Liu
  12. Lei Liu
  13. Liang Yang
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Abstract

This study characterized a genetically adapted Pseudomonas aeruginosa small colony variant isolated from a COVID-19 patient who suffered persistent bacterial coinfection and eventually recovered from critical illness. Specification and modification of the isolates discovered at genomic and transcriptomic levels with aligned phenotypic observations indicated that these isolates formed excessive biofilm with elevated quorum sensing systems.

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