Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women

  1. Mai He
  2. Priya Skaria
  3. Kasey Kreutz
  4. Ling Chen
  5. Ian Hagemann
  6. Ebony B. Carter
  7. Indira U. Mysorekar
  8. D Michael Nelson
  9. John Pfeifer
  10. Louis P. Dehner
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Abstract

This study aims to investigate whether maternal SARS-CoV-2 status affect placental pathology.

Methods

A retrospective case-control study was conducted by reviewing charts and slides of placentas between April 1 to July 24, 2020. Clinical history of “COVID-19” were searched in Pathology Database (CoPath). Controls were matched with SARS-CoV-2-negative women with singleton deliveries in the 3rd-trimester. Individual and group, pathological features were extracted from placental pathology reports.

Results

Twenty-one 3rd-trimester, placentas from SARS-CoV-2-positive women were identified and compared to 20 placentas from SARS-CoV-2-negative women. There were no significant differences in individual or group gross or microscopic pathological features between the groups. Within the SARS-CoV-2+ group, there are no differences between symptomatic and asymptomatic women.

Conclusion

Placentas from SARS-CoV-2-positive women do not demonstrate a specific pathological pattern. Pregnancy complicated with COVID-19 during the 3rd trimester does not have a demonstrable effect on placental structure and pathology.

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