Immunoreactive peptide maps of SARS-CoV-2 and other human coronaviruses

  1. Nischay Mishra
  2. Xi Huang
  3. Shreyas Joshi
  4. Cheng Guo
  5. James Ng
  6. Riddhi Thakkar
  7. Yongjian Wu
  8. Xin Dong
  9. Qianlin Li
  10. Richard Pinapati
  11. Eric Sullivan
  12. Adrian Caciula
  13. Rafal Tokarz
  14. Thomas Briese
  15. Jiahai Lu
  16. W. Ian Lipkin
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Abstract

Serodiagnosis of SARS-CoV-2 infection is impeded by immunological cross-reactivity to the human coronaviruses (HCoV) SARS-CoV-2, SARS-CoV-1, MERS-CoV, OC43, 229E, HKU1, and NL63. Here we report the identification of humoral immune responses to SARS-CoV-2 and other HCoV peptides that can be used to detect asymptomatic, mild and, severe SARS-CoV-2 infections, and may enable the discovery of biomarkers for immunity following infection or vaccination.

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