SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19

  1. Elizabeth M. Anderson
  2. Caroline Diorio
  3. Eileen C. Goodwin
  4. Kevin O. McNerney
  5. Madison E. Weirick
  6. Sigrid Gouma
  7. Marcus J. Bolton
  8. Claudia P. Arevalo
  9. Julie Chase
  10. Philip Hicks
  11. Tomaz B. Manzoni
  12. Amy E. Baxter
  13. Kurt P. Andrea
  14. Chakkapong Burudpakdee
  15. Jessica H. Lee
  16. Laura A. Vella
  17. Sarah E. Henrickson
  18. Rebecca M. Harris
  19. E. John Wherry
  20. Paul Bates
  21. Hamid Bassiri
  22. Edward M. Behrens
  23. David T. Teachey
  24. Scott E. Hensley
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Abstract

SARS-CoV-2 antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike IgG titers compared to those with severe coronavirus disease 2019 (COVID-19), likely reflecting a longer time since onset of infection in MIS-C patients.

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