Is There a Correlation Between Pulmonary Inflammation Index With COVID-19 Disease Severity And Outcome?
Abstract
Rational
the radiologic pulmonary inflammatory index (PII) may be used as early predictor of inflammation as laboratory assessments in COVID-19 cases. The purpose of this study was to compare the clinical and radiological features between the cases of COVID-19 necessitating admittance to the intensive care unit (ICU) and those who did not, and to correlate the radiological pulmonary inflammation index (PII) with other inflammatory markers and outcome.
Patients and methods
This study included 72 patients consecutively admitted with confirmed COVID-19. Their electronic records of were retrospectively revised and the demographic, clinical, laboratory (complete blood count, C reactive protein, D dimer and serum ferritin), HRCT data, pulmonary inflammation index (PII) and the outcomes of the patients (ICU admission, death, recovery, and referral) were analyzed.
Results
They were 50/50% males/females, mean age was 47.1 ± 16.8 (median 47 years). During their stay, 15.3% necessitated ICU admittance, 49 (68%) cured and discharged, 9 cases referred and five cases (6.9%) died. The baseline lesions identified were ground glass opacification recognized in (93%), higher PII and >3 lobes affection were considerably recorded in those who required ICU admittance (P= 0.041 and 0.013). There were moderate positive correlations between PII with age (r=0.264, P=0.031) and other prognostic inflammatory indicators as ferritin (r=0.225, P=0.048), D Dimer (r=0.271, P=0.043) and serum creatinine.
Conclusions
The use of PII together with clinical and laboratory data may be valuable in defining the inflammatory state of COVID-19. It was correlated with other inflammatory indices as D dimer, ferritin even before clinical deterioration. This may allow clinicians to avoid the progression of the illness and improve cure rates by proper early intervention.
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