Shedding of infectious SARS-CoV-2 from airways in hospitalized COVID-19 patients in relation to serum antibody responses

  1. Hedvig Glans
  2. Sara Gredmark-Russ
  3. Mikaela Olausson
  4. Sara Falck-Jones
  5. Renata Varnaite
  6. Wanda Christ
  7. Kimia T. Maleki
  8. Maria Lind Karlberg
  9. Sandra Broddesson
  10. Ryan Falck-Jones
  11. Max Bell
  12. Niclas Johansson
  13. Anna Färnert
  14. Anna Smed-Sörensen
  15. Jonas Klingström
  16. Andreas Bråve
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Abstract

To understand the risk of transmission of SARS-CoV-2 in hospitalized COVID-19 patients we simultaneously assessed the presence of SARS-CoV-2 RNA, live infectious virus in the airways, and virus-specific IgG and neutralizing antibodies in sera in 36 hospitalized COVID-19 patients. SARS-CoV-2 could be cultured from four patients, all with low or undetectable antibody response. Our data suggests that the level of SARS-CoV-2 antibodies may correlate to risk for shedding live SARS-CoV-2 virus in hospitalized COVID-19 patients.

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