Impact of SARS-CoV-2 antibodies at delivery in women, partners and newborns

  1. Pia Egerup
  2. Line Fich Olsen
  3. Ann-Marie Hellerung Christiansen
  4. David Westergaard
  5. Elin Rosenbek Severinsen
  6. Kathrine Vauvert Römmelmayer Hviid
  7. Astrid Marie Kolte
  8. Amalie Dyhrberg Boje
  9. Marie-Louise Mathilde Friis Bertelsen
  10. Lisbeth Prætorius
  11. Anne Zedeler
  12. Josefine Reinhardt Nielsen
  13. Didi Bang
  14. Sine Berntsen
  15. Jeppe Ethelberg-Findsen
  16. Ditte Marie Storm
  17. Judith Bello-Rodríguez
  18. Andreas Ingham
  19. Joaquim Ollé-López
  20. Eva R Hoffmann
  21. Charlotte Wilken-Jensen
  22. Lone Krebs
  23. Finn Stener Jørgensen
  24. Henrik Westh
  25. Henrik Løvendahl Jørgensen
  26. Nina la Cour Freiesleben
  27. Henriette Svarre Nielsen
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Abstract

Background

Only few studies have focused on serological testing for SARS-CoV-2 in pregnant women and no previous study has investigated the frequency in partners. The aim was to investigate the frequency and impact of SARS-CoV-2 in parturient women, their partners and newborns.

Methods

From April 4thto July 3rd, 2020, all parturient women, their partners and newborns were invited to participate in the study. Participating women and partners had a pharyngeal swab and a blood sample taken at admission and immediately after delivery a blood sample was drawn from the umbilical cord. The swabs were analyzed for SARS-CoV-2 RNA by PCR and the blood samples were analyzed for SARS-CoV-2 antibodies. Full medical history, obstetric- and neonatal information were available.

Results

A total of 1,361 parturient women, 1,236 partners and 1,342 newborns participated in the study. No associations between previous COVID-19 disease and obstetric- or neonatal complications were found. The adjusted serological prevalence was 2.9% in women and 3.8% in partners. The frequency of blood type A was significantly higher in women with antibodies compared to women without antibodies. 17 newborns had SARS-CoV-2 IgG antibodies, and none had IgM antibodies. Full serological data from 1,052 families showed an absolute risk of infection of 0.37 if the partner had antibodies. Only 55% of individuals with antibodies reported symptoms.

Conclusion

This large prospective cohort study reports no association between COVID-19 and obstetric- or neonatal complications. The family pattern showed a substantial increase in absolute risk for women living with a partner with antibodies.

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