A Comparative COVID 19 Characterizations and Clinical Course Analysis between ICU and Non ICU Settings

  1. Amit Patel
  2. Parloop Bhatt
  3. Surabhi Madan
  4. Nitesh Shah
  5. Vipul Thakkar
  6. Bhagyesh Shah
  7. Rashmi Chovatia
  8. Hardik Shah
  9. Minesh Patel
  10. Pradip Dabhi
  11. Aditi Nanavati
  12. Milan Chag
  13. Keyur Parikh
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Abstract

Objective

With COVID-19 pandemic severely affecting India and Ahmedabad city being one accounting for half COVID cases, objective was to determine disease course and severity of in patients at a COVID care hospital.

Design

A Clinical trial registry of India registered observational study (CTRI/2020/05/025247).

Setting

C ertified COVID hospital located in Ahmedabad, Gujarat, India.

Participants

549 COVID positive patients hospitalized between 15 th May to 10 th August, 2020 and treated in ICU and non ICU settings.

Main Outcome Measure

Comparative analysis of demographic, clinical characteristics, investigations, treatment, complications and outcome of COVID patients in ICU and non ICU settings.

Results

Of the 549 hospitalized COVID positive patients, 159 were admitted in ICU during disease course while 390 had ward admissions. Overall median age was 52 (1-86) years. The ICU group was older (>65years), with associated comorbidities like hypertension and diabetes (p<0.001); higher proportion of males (79.25%); with dyspnea as a major clinical characteristic and consolidation in lungs as a major radiological finding as compared to ward patients. C - reactive protein, D-Dimer and Ferritin were higher in ICU patients. Overall 50% females depicted elevated Ferritin levels. Steriods(92.45%)and tocilizumab (69.18%) were more frequently used for ICU patients. Remdesivir was prescribed to both ICU and non ICU patients. Favirapir was also a line of treatment for 25% of ICU patients. Convalescent plasma therapy was given to 7 ICU patients. Complications like acute kidney injury (13.84%), shock (10.69 %), sepsis and encephalopathy were observed in ICU patients. Overall mortality rate was 5.47 % with higher mortality among males in comparison to females (p<0.0001).

Conclusion

About 29% of overall patients required ICU admission that was commonly elderly males. Chances of ICU admission were higher with baselines comorbidities (1.5 times) and dyspnea (3.4 times) respectively. A multi-specialty COVID care team and updated treatment protocols improves outcomes.

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