The wide spectrum of neuropsychiatric complications in Covid-19 patients within a multidisciplinary hospital context

  1. Cécile Delorme
  2. Marion Houot
  3. Charlotte Rosso
  4. Stéphanie Carvalho
  5. Thomas Nedelec
  6. Redwan Maatoug
  7. Victor Pitron
  8. Salimata Gassama
  9. Sara Sambin
  10. Stéphanie Bombois
  11. Bastien Herlin
  12. Gaëlle Ouvrard
  13. Gaëlle Bruneteau
  14. Adèle Hesters
  15. Ana Zenovia Gales
  16. Bruno Millet
  17. Foudil Lamari
  18. Stéphane Lehericy
  19. Vincent Navarro
  20. Benjamin Rohaut
  21. Sophie Demeret
  22. Thierry Maisonobe
  23. Marion Yger
  24. Bertrand Degos
  25. Louise-Laure Mariani
  26. Christophe Bouche
  27. Nathalie Dzierzynski
  28. Bruno Oquendo
  29. Flora Ketz
  30. An-Hung Nguyen
  31. Aurélie Kas
  32. Jean-Yves Delattre
  33. Jean-Christophe Corvol
1 evaluations Published on
Read the full article Related papers
This article on Sciety

Abstract

Objective

To describe the spectrum of neurological and psychiatric complications in patients with Covid-19 seen in a multidisciplinary center over six months.

Methods

We conducted a retrospective, observational study on all patients showing neurological or psychiatric symptoms in the context of Covid-19 seen in the Department of Neurology and Psychiatry of the APHP-Sorbonne University. We collected demographic data, medical and treatment history, comorbidities, symptoms, date of onset, and severity of Covid-19 infection, neurological and psychiatric symptoms, neurological and psychiatric examination data and, when available, results from cerebrospinal fluid (CSF) analysis, brain magnetic resonance (MRI) imaging, 18-fluorodesoxyglucose-position emission computed tomography (FDG-PET/CT)), electroencephalography (EEG) and electroneuromyography (ENMG).

Results

245 patients were included in the analysis. One-hundred fourteen patients (47%) were admitted to the intensive care unit (ICU) and 10 (4%) died. The most frequently reported neuropsychiatric symptoms were motor deficit (41%), cognitive disturbance (35%), impaired consciousness (26%), psychiatric disturbance (24%), headache (20%) and behavioral disturbance (18%). The most frequent syndromes diagnosed were encephalopathy (43%), critical illness polyneuropathy and myopathy (26%), isolated psychiatric disturbance (18%), and cerebrovascular disorders (16%). No patients showed evidence of SARS-CoV-2 in their CSF. Encephalopathy was associated with greater age and higher risk of death. Critical illness neuromyopathy was associated with an extended stay in the ICU.

Conclusions

The majority of the neuropsychiatric complications recorded could be imputed to critical illness, intensive care and systemic inflammation, which contrasts with the paucity of more direct SARS-CoV-2-related complications or post-infection disorders.

Related articles

Related articles are currently not available for this article.