Host genetic liability for severe COVID-19 overlaps with alcohol drinking behavior and diabetic outcomes in over 1 million participants

  1. Frank R Wendt
  2. Antonella De Lillo
  3. Gita A Pathak
  4. Flavio De Angelis
  5. COVID-19 Host Genetics Initiative
  6. Renato Polimanti
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Abstract

To distinguish correlation from causation, we performedin-silicoanalyses of three COVID-19 outcomes (N>1,000,000). We show genetic correlation and putative causality with depressive symptoms, metformin use, and alcohol use. COVID-19 risk loci associated with several hematologic biomarkers. Comprehensive findings inform genetic contributions to COVID-19 epidemiology, molecular mechanisms, and risk factors.

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