Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes

  1. Julia A. Zakashansky
  2. Amanda H. Imamura
  3. Darwin F. Salgado
  4. Heather C. Romero Mercieca
  5. Raphael F.L. Aguas
  6. Angelou M. Lao
  7. Joseph Pariser
  8. Netzahualcóyotl Arroyo-Currás
  9. Michelle Khine
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Abstract

Using the children’s toy, Shrinky-Dink ©, we present an aptamer-based electrochemical (E-AB) assay that recognizes the spike protein of SARS-CoV-2 in saliva for viral infection detection. The low-cost electrodes are implementable at population scale and demonstrate detection down to 0.1 fg mL −1 of the S1 subunit of the spike protein.

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