Prolonged presence of replication-competent SARS-CoV-2 in mildly symptomatic individuals: A Report of 2 Cases

  1. Maria Cassia Mendes-Correa
  2. Fabio E. Leal
  3. Lucy S. Villas-Boas
  4. Steven S. Witkin
  5. Anderson de Paula
  6. Tania Regina Tozetto-Mendonza
  7. Noely Evangelista Ferreira
  8. Gislaine Curty
  9. Pedro Santos de Carvalho
  10. Lewis F. Buss
  11. Silvia F. Costa
  12. Flavia Mendes da Cunha Carvalho
  13. Joyce Kawakami
  14. Noemi Nosomi Taniwaki
  15. Heuder Paiao
  16. Joao Carlos da Silva Bizário
  17. Jaqueline Goes de Jesus
  18. Ester Cerdeira Sabino
  19. Camila Malta Romano
  20. Regina Maura Zetone Grepan
  21. Antonio Sesso
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Abstract

It has been estimated that individuals with COVID-19 can shed replication-competent virus up to a maximum of twenty days after initiation of symptoms. This report describes two patients with mild forms of the disease who shed replication-competent virus for 24 and 37 days, respectively, after symptom onset.

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