Household factors and the risk of severe COVID-like illness early in the US pandemic

  1. Denis Nash
  2. Saba Qasmieh
  3. McKaylee Robertson
  4. Madhura Rane
  5. Rebecca Zimba
  6. Sarah Kulkarni
  7. Amanda Berry
  8. William You
  9. Chloe Mirzayi
  10. Drew Westmoreland
  11. Angela Parcesepe
  12. Levi Waldron
  13. Shivani Kochhar
  14. Andrew R Maroko
  15. Christian Grov
  16. for the CHASING COVID Cohort Study Team
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Abstract

Objective

To investigate the role of children in the home and household crowding as risk factors for severe COVID-19 disease.

Methods

We used interview data from 6,831 U.S. adults screened for the Communities, Households and SARS/CoV-2 Epidemiology (CHASING) COVID Cohort Study in April 2020.

Results

In logistic regression models, the adjusted odds ratio [aOR] of hospitalization due to COVID-19 for having (versus not having) children in the home was 10.5 (95% CI:5.7-19.1) among study participants living in multi-unit dwellings and 2.2 (95% CI:1.2-6.5) among those living in single unit dwellings. Among participants living in multi-unit dwellings, the aOR for COVID-19 hospitalization among participants with more than 4 persons in their household (versus 1 person) was 2.5 (95% CI:1.0-6.1), and 0.8 (95% CI:0.15-4.1) among those living in single unit dwellings.

Conclusion

Early in the US SARS-CoV-2 pandemic, certain household exposures likely increased the risk of both SARS-CoV-2 acquisition and the risk of severe COVID-19 disease.

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