Human embryonic stem cell-derived cardiomyocytes express SARS-CoV-2 host entry proteins: screen to identify inhibitors of infection

  1. Thomas L. Williams
  2. Maria T. Colzani
  3. Robyn G.C. Macrae
  4. Emma L. Robinson
  5. Stuart Bloor
  6. Edward J. D. Greenwood
  7. Jun Ru Zhan
  8. Gregory Strachan
  9. Rhoda E. Kuc
  10. Duuamene Nyimanu
  11. Janet J. Maguire
  12. Paul J. Lehner
  13. Sanjay Sinha
  14. Anthony P. Davenport
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Abstract

Patients with cardiovascular comorbidities are more susceptible to severe infection with SARS-CoV-2, known to directly cause pathological damage to cardiovascular tissue. We outline a screening platform using human embryonic stem cell-derived cardiomyocytes, confirmed to express the protein machinery critical for SARS-CoV-2 infection, and a pseudotyped virus system. The method has allowed us to identify benztropine and DX600 as novel inhibitors of SARS-CoV-2 infection.

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