Decreased SARS-CoV-2 viral load following vaccination

  1. Matan Levine-Tiefenbrun
  2. Idan Yelin
  3. Rachel Katz
  4. Esma Herzel
  5. Ziv Golan
  6. Licita Schreiber
  7. Tamar Wolf
  8. Varda Nadler
  9. Amir Ben-Tov
  10. Jacob Kuint
  11. Sivan Gazit
  12. Tal Patalon
  13. Gabriel Chodick
  14. Roy Kishony
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Abstract

Beyond their substantial protection of individual vaccinees, it is hoped that the COVID-19 vaccines would reduce viral load in breakthrough infections thereby further suppress onward transmission. Here, analyzing positive SARS-CoV-2 test results following inoculation with the BNT162b2 mRNA vaccine, we find that the viral load is reduced 4-fold for infections occurring 12-28 days after the first dose of vaccine. These reduced viral loads hint to lower infectiousness, further contributing to vaccine impact on virus spread.

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