The changing characteristics of COVID-19 presentations: A regional comparison of SARS-CoV-2 hospitalised patients during the first and second wave

  1. Catherine Atkin
  2. Vicky Kamwa
  3. V Reddy-Kolanu
  4. D Parekh
  5. Felicity Evison
  6. Peter Nightingale
  7. Suzy Gallier
  8. Simon Ball
  9. Elizabeth Sapey
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Abstract

Background

This study assesses COVID-19 hospitalised patient demography and outcomes during wave 1 and wave 2, prior to new variants of the virus.

Methods

All patients with a positive SARS-CoV-2 swab between 10 th March 2020 and 5 th July 2020 (wave 1) and 1 st September 2020 and 16 th November 2020 (wave 2) admitted to University Hospitals Birmingham NHS Foundation Trust were included (n=4856), followed for 28 days.

Results

Wave 2 patients were younger, more ethnically diverse, had less co-morbidities and disease presentation was milder on presentation. After matching for these factors, mortality was reduced, but without differences in intensive care admissions.

Conclusion

Prior to new SARS-CoV-2 variants, outcomes for hospitalised patients with COVID-19 were improving but with similar intensive care needs.

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