T-cell Repertoire Characteristics of Asymptomatic and Re-detectable Positive COVID-19 Patients

  1. Jianhua Xu
  2. Yaling Shi
  3. Yongsi Wang
  4. Yuntao Liu
  5. Dongzi Lin
  6. Jiaqi Zhang
  7. Jing Lin
  8. Wei Hu
  9. Haolan He
  10. Wei Wang
  11. Wentao Fan
  12. Linlin Li
  13. Hai Lan
  14. Chunliang Lei
  15. Kejian Wang
  16. Dawei Wang
1 evaluations Published on
Read the full article Related papers
This article on Sciety

Abstract

Background

The prevention of COVID-19 pandemic is highly complicated by the prevalence of asymptomatic and recurrent infection. Many previous immunological studies have focused on symptomatic and convalescent patients, while the immune responses in asymptomatic patients and re-detectable positive cases remain unclear.

Methods

Here we comprehensively analyzed the peripheral T-cell receptor (TCR) repertoire of 54 COVID-19 patients in different phases, including asymptomatic, symptomatic, convalescent and re-detectable positive cases.

Results

We found progressed immune responses from asymptomatic to symptomatic phase. Furthermore, the TCR profiles of re-detectable positive cases were highly similar to those of asymptomatic patients, which could predict the risk of recurrent infection.

Conclusion

Therefore, TCR repertoire surveillance has the potential to strengthen the clinical management and the immunotherapy development for COVID-19.

Funding

The Science and Technology Innovation Project of Foshan Municipality (2020001000431) and the National Key Research and Development Project (2020YFA0708001).

Related articles

Related articles are currently not available for this article.