Naturally-acquired immunity in Syrian Golden Hamsters provides protection from re-exposure to emerging heterosubtypic SARS-CoV-2 variants B.1.1.7 and B.1.351

  1. Jordan J. Clark
  2. Parul Sharma
  3. Eleanor G. Bentley
  4. Adam C. Harding
  5. Anja Kipar
  6. Megan Neary
  7. Helen Box
  8. Grant L. Hughes
  9. Edward I. Patterson
  10. Jo Sharp
  11. Tulio de Oliveira
  12. Alex Sigal
  13. Julian A. Hiscox
  14. William S. James
  15. Miles W. Carroll
  16. Andrew Owen
  17. James P. Stewart
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Abstract

The ability of acquired immune responses against SARS-CoV-2 to protect after subsequent exposure to emerging variants of concern (VOC) such as B1.1.7 and B1.351 is currently of high significance. Here, we use a hamster model of COVID-19 to show that prior infection with a strain representative of the original circulating lineage B of SARS-CoV-2 induces protection from clinical signs upon subsequent challenge with either B1.1.7 or B1.351 viruses, which recently emerged in the UK and South Africa, respectively. The results indicate that these emergent VOC may be unlikely to cause disease in individuals that are already immune due to prior infection, and this has positive implications for overall levels of infection and COVID-19 disease.

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