A novel whole-blood stimulation assay to detect and quantify memory T-cells in COVID-19 patients

  1. William Mouton
  2. Christelle Compagnon
  3. Kahina Saker
  4. Soizic Daniel
  5. Xavier Lacoux
  6. Bruno Pozzetto
  7. Guy Oriol
  8. Sophia Djebali
  9. Franck Berthier
  10. Jacqueline Marvel
  11. Thierry Walzer
  12. Karen Brengel-Pesce
  13. Sophie Trouiller-Assant
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Abstract

SARS-CoV-2 specific T-cells responses are essential for virus clearance. We present a novel and simple whole-blood assay allowing the detection of interferon-gamma-producing antiviral T-cells following peptide stimulation. We show that unlike neutralizing antibodies, antiviral memory T-cells persist at least 6 months in convalescent Covid-19 individuals.

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